Haemorrhagic disease of the newborn.

The transitory absence of several clotting factors in a newborn baby.

Haemorrhagic diathesis of the newborn is usually characterized by a physiological deficiency of prothrombin and probably also by a deficiency of proconvertin (van Creveld, Paulssen, Ens, Mey, Versteegh and Versteeg, 1954). Sometimes a third clotting-factor, pro-accelerin, is also lacking. We found a simultaneous deficiency both of prothrombin and pro-accelerin in some cases of intra-uterine mel...

Haemorrhagic disease of the newborn in the British Isles: two year prospective study.

OBJECTIVE To determine the incidence of haemorrhagic disease of the newborn in the British Isles, study risk factors, and examine the effect of vitamin K prophylaxis. DESIGN Prospective survey of all possible cases of haemorrhagic disease of the newborn as reported by consultant paediatricians using the monthly notification cards of the British Paediatric Surveillance Unit and a follow up que...

Risk factors, presentations and outcome of the haemorrhagic disease of newborn.

OBJECTIVE To determine the presentations, associated factors and acute outcome in the haemorrhagic disease of newborn. STUDY DESIGN Cross-sectional analytical study. PLACE AND DURATION OF STUDY Paediatric Medicine Unit II, Nishtar Hospital, Multan, from June 2004 to May 2006. METHODOLOGY Fifty patients with haemorrhagic disease of newborn were studied. Age at onset of symptoms, gender, fe...

The effect of large doses of synkavit in the newborn.

Experimental work during the years 1929 to 1934 established the fact that a haemorrhagic disease observed in chicks was due to deficiency of a fatsoluble dietary factor: in 1935 Dam proposed the nane vitamin K (Koagulations vitamin) for this factor. Dam, Sch0nheyder and Tage-Hansen in 1936 demonstrated a hypoprothrombinaemia which prolonged the clotting time in vitamin-K-deficient chicks, altho...

Vitamin K and haemorrhagic disease of the newborn.